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Acetaminophen

Acetaminophen

Before taking acetaminophen
Before taking acetaminophen, make sure your doctor, dentist or pharmacist knows:
If you are allergic to acetaminophen, or any other medications
If you have other medical problems, specially:
  • Alcoholism (active);
  • Hepatic disease;
  • Viral hepatitis; or
  • Renal function impairment, severe
If you are taking other medications such as: Barbiturates, Anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs), Aspirin or other salicylates, other products containing acetaminophen.





Proper use of acetaminophen
  • Do not take more of this medication than the amount recommended. Use acetaminophen exactly as prescribed by your doctor.
  • Possible interference with some laboratory tests; preferably discussing use of this medication with physician in charge 3 to 4 days ahead of time; if this is not possible, informing physician in charge if acetaminophen taken within the past 3 or 4 days.
  • Diabetics: Possible false results with blood glucose tests; checking with physician, nurse or pharmacist if changes in test results noted.
Warnings
  • Risk of overdose if other medications containing acetaminophen are used.
  • Risk of hepatotoxicity may be increased if acetaminophen used with alcohol.
  • It is recommended that children up to 12 years of age receive no more than five doses in each twenty-four-hour period, unless otherwise directed by a physician.
Precaution while using acetaminophen
Checking with physician because additional treatment may be needed:
  • If taking for pain, and pain persists for longer than 10 days for adults or 5 days for children, condition becomes worse, new symptoms occur, or the painful area is red or swollen.
  • If taking for fever, and fever persists for longer than 3 days, condition becomes worse, or new symptoms occur.
  • If taking for sore throat, and sore throat is severe, persists for longer than 2 days, or occurs together with or is followed by fever, headache, rash, nausea, or vomiting.
Dosage and administration

Usual adult and adolescent dose
Analgesic and antipyretic:
  • 325 to 500 mg every three hours
  • 325 to 650 mg every four hours
  • 650 mg to 1 gram every six hours as needed, or
  • 1300 mg every 8 hours, while symptoms persist
Usual adult prescribing limits
  • Up to 4 grams daily
Usual pediatric dose
Analgesic and antipyretic:
  • Oral, 1.5 grams per square meter of body surface a day in divided doses; or for
  • Infants up to 3 months of age: Oral, 40 mg every four hours as needed
  • Infants 4 to 12 months of age: Oral, 80 mg every four hours as needed
  • Children 1 to 2 years of age: Oral, 120 mg every four hours as needed
  • Children 2 to 4 years of age: Oral, 160 mg every 4 hours as needed, while symptoms persist
  • Children 4 to 6 years of age: Oral, 240 mg every 4 hours as needed, while symptoms persist
  • Children 6 to 9 years of age: Oral, 320 mg every 4 hours as needed, while symptoms persist
  • Children 9 to 11 years of age: Oral, 320 to 400 mg every 4 hours as needed, while symptoms persist
  • Children 11 to 12 years of age: Oral, 320 to 480 mg every 4 hours as needed, while symptoms persist
Side/ Adverse effect
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them.

Those indicating need for medical attention

Incidence rare
  • Agranulocytosis (fever with or without chills; sores, ulcers, or white spots on lips or in mouth; sore throat);
  • Anemia (unusual tiredness or weakness);
  • Dermatitis allergic (skin rash, hives, or itching);
  • Hepatitis (yellow eyes or skin);
  • Renal colic (pain, severe and/or sharp, in lower back and/or side) - with prolonged use of high doses in patients with severe renal function impairment;
  • Renal failure (sudden decrease in amount of urine);
  • Sterile pyuria (cloudy urine);
  • Thrombocytopenia (rarely, unusual bleeding or bruising; black, tarry stools; blood in urine or stools; pinpoint red spots on skin)
Overdose
  • In case of overdose, contact a poison control center.
  • Symptoms of acetaminophen overdosage may occur 2 to 4 days after ingestion of the overdose, but treatment must be begun as soon as possible to prevent liver damage or fatality; treatment started 24 hours or more after the overdose may be ineffective in preventing complications of overdose.

Storage
  • Store below 30 and in a tight container. Protect from freezing.
  • Keep this medicine out of the reach of children.


 




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